解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::TBK1 is essential for interferon-β (IFN-β) production and innate antiviral immunity. Here we identified the T cell anergy-related E3 ubiquitin ligase RNF128 as a positive regulator of TBK1 activation. RNF128 directly interacted with TBK1 through its protease-associated (PA) domain and catalyzed the K63-linked polyubiq...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3588
更新日期:2016-12-01 00:00:00
abstract::Regions of the normal arterial intima predisposed to atherosclerosis are sites of ongoing monocyte trafficking and also contain resident myeloid cells with features of dendritic cells. However, the pathophysiological roles of these cells are poorly understood. Here we found that intimal myeloid cells underwent reverse...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3564
更新日期:2016-11-01 00:00:00
abstract::During unresolved infections, some viruses escape immunological control and establish a persistant reservoir in certain cell types, such as human immunodeficiency virus (HIV), which persists in follicular helper T cells (TFH cells), and Epstein-Barr virus (EBV), which persists in B cells. Here we identified a speciali...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3543
更新日期:2016-10-01 00:00:00
abstract::The manner in which regulatory T cells (Treg cells) control lymphocyte homeostasis is not fully understood. We identified two Treg cell populations with differing degrees of self-reactivity and distinct regulatory functions. We found that GITR(hi)PD-1(hi)CD25(hi) (Triple(hi)) Treg cells were highly self-reactive and c...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3522
更新日期:2016-09-01 00:00:00
abstract::Microbial infections often precede the onset of autoimmunity. How infections trigger autoimmunity remains poorly understood. We investigated the possibility that infection might create conditions that allow the stimulatory presentation of self peptides themselves and that this might suffice to elicit autoreactive T ce...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3512
更新日期:2016-09-01 00:00:00
abstract::During T cell development, multipotent progenitors relinquish competence for other fates and commit to the T cell lineage by turning on Bcl11b, which encodes a transcription factor. To clarify lineage commitment mechanisms, we followed developing T cells at the single-cell level using Bcl11b knock-in fluorescent repor...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3514
更新日期:2016-08-01 00:00:00
abstract::Deficiency in mevalonate kinase (MVK) causes systemic inflammation. However, the molecular mechanisms linking the mevalonate pathway to inflammation remain obscure. Geranylgeranyl pyrophosphate, a non-sterol intermediate of the mevalonate pathway, is the substrate for protein geranylgeranylation, a protein post-transl...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3487
更新日期:2016-08-01 00:00:00
abstract::Immunologists are being compelled to develop new high-dimensional perspectives of cellular heterogeneity and to determine which applications best exploit the power of mass cytometry and associated multiplex approaches. ...
journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni.3485
更新日期:2016-07-19 00:00:00
abstract::The detection of aberrant cells by natural killer (NK) cells is controlled by the integration of signals from activating and inhibitory ligands and from cytokines such as IL-15. We identified cytokine-inducible SH2-containing protein (CIS, encoded by Cish) as a critical negative regulator of IL-15 signaling in NK cell...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3470
更新日期:2016-07-01 00:00:00
abstract::T cell antigen receptor (TCR) signaling drives distinct responses depending on the differentiation state and context of CD8(+) T cells. We hypothesized that access of signal-dependent transcription factors (TFs) to enhancers is dynamically regulated to shape transcriptional responses to TCR signaling. We found that th...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3441
更新日期:2016-07-01 00:00:00
abstract::According to current models of hematopoiesis, lymphoid-primed multi-potent progenitors (LMPPs) (Lin(-)Sca-1(+)c-Kit(+)CD34(+)Flt3(hi)) and common myeloid progenitors (CMPs) (Lin(-)Sca-1(+)c-Kit(+)CD34(+)CD41(hi)) establish an early branch point for separate lineage-commitment pathways from hematopoietic stem cells, wi...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3412
更新日期:2016-06-01 00:00:00
abstract::Natural killer T cells (NKT cells) have stimulatory or inhibitory effects on the immune response that can be attributed in part to the existence of functional subsets of NKT cells. These subsets have been characterized only on the basis of the differential expression of a few transcription factors and cell-surface mol...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3437
更新日期:2016-06-01 00:00:00
abstract::The bidirectional interaction between the immune system and whole-body metabolism has been well recognized for many years. Via effects on adipocytes and hepatocytes, immune cells can modulate whole-body metabolism (in metabolic syndromes such as type 2 diabetes and obesity) and, reciprocally, host nutrition and commen...
journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni.3466
更新日期:2016-05-19 00:00:00
abstract::Autoreactive B cells have critical roles in a large diversity of autoimmune diseases, but the molecular pathways that control these cells remain poorly understood. We performed an in vivo functional screen of a lymphocyte-expressed microRNA library and identified miR-148a as a potent regulator of B cell tolerance. Ele...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3385
更新日期:2016-04-01 00:00:00
abstract::Regulatory T (Treg) cells respond to immune and inflammatory signals to mediate immunosuppression, but how the functional integrity of Treg cells is maintained under activating environments is unclear. Here we show that autophagy is active in Treg cells and supports their lineage stability and survival fitness. Treg c...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3365
更新日期:2016-03-01 00:00:00
abstract::The Greek island of Crete became host to lively discussions on immunoregulation as experts from around the world gathered for the 7th Aegean Conference on Autoimmunity in September 2015. ...
journal_title:Nature immunology
pub_type:
doi:10.1038/ni.3367
更新日期:2016-03-01 00:00:00
abstract::Plasma cell differentiation requires silencing of B cell transcription, while it establishes antibody-secretory function and long-term survival. The transcription factors Blimp-1 and IRF4 are essential for the generation of plasma cells; however, their function in mature plasma cells has remained elusive. We found tha...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3348
更新日期:2016-03-01 00:00:00
abstract::Mucosal surfaces are exposed to environmental substances and represent a major portal of entry for microorganisms. The innate immune system is responsible for early defense against infections and it is believed that the interferons (IFNs) constitute the first line of defense against viruses. Here we identify an innate...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3319
更新日期:2016-02-01 00:00:00
abstract::We used high-resolution mass spectrometry to map the cytotoxic T lymphocyte (CTL) proteome and the effect of the metabolic checkpoint kinase mTORC1 on CTLs. The CTL proteome was dominated by metabolic regulators and granzymes, and mTORC1 selectively repressed and promoted expression of a subset of CTL proteins (~10%)....
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3314
更新日期:2016-01-01 00:00:00
abstract::Macrophages have protective roles in immunity to pathogens, tissue development, homeostasis and repair following damage. Maladaptive immunity and inflammation provoke changes in macrophage function that are causative of disease. Despite a historical wealth of knowledge about macrophages, recent advances have revealed ...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3324
更新日期:2016-01-01 00:00:00
abstract::To investigate if the microRNA (miRNA) pathway is required for dendritic cell (DC) development, we assessed the effect of ablating Drosha and Dicer, the two enzymes central to miRNA biogenesis. We found that while Dicer deficiency had some effect, Drosha deficiency completely halted DC development and halted myelopoie...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3293
更新日期:2015-11-01 00:00:00
abstract::Immunological memory is thought to be mediated exclusively by lymphocytes. However, enhanced innate immune responses caused by a previous infection increase protection against reinfection, which suggests the presence of innate immunological memory. Here we identified an important role for the stress-response transcrip...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3257
更新日期:2015-10-01 00:00:00
abstract::Autophagy is an intracellular bulk degradation system that is highly conserved in eukaryotes. The discovery of autophagy-related ('ATG') proteins in the 1990s greatly advanced the mechanistic understanding of autophagy and clarified the fact that autophagy serves important roles in various biological processes. In add...
journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni.3273
更新日期:2015-10-01 00:00:00
abstract::The transcription factor Aire controls immunological tolerance by inducing the ectopic thymic expression of many tissue-specific genes, acting broadly by removing stops on the transcriptional machinery. To better understand Aire's specificity, we performed single-cell RNA-seq and DNA-methylation analysis of Aire-suffi...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3247
更新日期:2015-09-01 00:00:00
abstract::Natural killer (NK) cells have traditionally been considered nonspecific components of innate immunity, but recent studies have shown features of antigen-specific memory in mouse NK cells. However, it has remained unclear whether this phenomenon also exists in primates. We found that splenic and hepatic NK cells from ...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3227
更新日期:2015-09-01 00:00:00
abstract::Induction of the transcriptional repressor Bcl-6 in CD4(+) T cells is critical for the differentiation of follicular helper T cells (T(FH) cells), which are essential for B cell-mediated immunity. In contrast, the transcription factor Blimp1 (encoded by Prdm1) inhibits T(FH) differentiation by antagonizing Bcl-6. Here...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3229
更新日期:2015-09-01 00:00:00
abstract::Mouse conventional dendritic cells (cDCs) can be classified into two functionally distinct lineages: the CD8α(+) (CD103(+)) cDC1 lineage, and the CD11b(+) cDC2 lineage. cDCs arise from a cascade of bone marrow (BM) DC-committed progenitor cells that include the common DC progenitors (CDPs) and pre-DCs, which exit the ...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3200
更新日期:2015-07-01 00:00:00
abstract::The outcome after infection with the human immunodeficiency virus type 1 (HIV-1) is a complex phenotype determined by interactions among the pathogen, the human host and the surrounding environment. An impact of host genetic variation on HIV-1 susceptibility was identified early in the pandemic, with a major role attr...
journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni.3147
更新日期:2015-06-01 00:00:00
abstract::The human helicase senataxin (SETX) has been linked to the neurodegenerative diseases amyotrophic lateral sclerosis (ALS4) and ataxia with oculomotor apraxia (AOA2). Here we identified a role for SETX in controlling the antiviral response. Cells that had undergone depletion of SETX and SETX-deficient cells derived fro...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3132
更新日期:2015-05-01 00:00:00
abstract::Mycobacterium tuberculosis PtpA, a secreted tyrosine phosphatase essential for tuberculosis pathogenicity, could be an ideal target for a drug against tuberculosis, but its active-site inhibitors lack selectivity over human phosphatases. Here we found that PtpA suppressed innate immunity dependent on pathways of the k...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3096
更新日期:2015-03-01 00:00:00
abstract::Innate lymphoid cells (ILCs) are lymphocyte-like cells that lack T cell or B cell antigen receptors and mediate protective and repair functions through cytokine secretion. Among these, type 2 ILCs (ILC2 cells) are able to produce type 2 cytokines. We report the existence of an inflammatory ILC2 (iILC2) population resp...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3078
更新日期:2015-02-01 00:00:00
abstract::Regulatory T cells (Treg cells) can express the transcription factors T-bet and GATA-3, but the function of this expression and whether such cells represent stable subsets is still unknown. By using various reporter tools, we found that the expression of T-bet and GATA-3 in Treg cells was dynamically influenced by the...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3053
更新日期:2015-02-01 00:00:00
abstract::MicroRNAs (miRNAs) exert powerful effects on immunological function by tuning networks of target genes that orchestrate cell activity. We sought to identify miRNAs and miRNA-regulated pathways that control the type 2 helper T cell (TH2 cell) responses that drive pathogenic inflammation in asthma. Profiling miRNA expre...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3026
更新日期:2014-12-01 00:00:00
abstract::Humoral autoimmunity paralleled by the accumulation of follicular helper T cells (T(FH) cells) is linked to mutation of the gene encoding the RNA-binding protein roquin-1. Here we found that T cells lacking roquin caused pathology in the lung and accumulated as cells of the T(H)17 subset of helper T cells in the lungs...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3008
更新日期:2014-11-01 00:00:00
abstract::The transcription factor ThPOK promotes CD4(+) T cell differentiation in the thymus. Here, using a mouse strain that allows post-thymic gene deletion, we show that ThPOK maintains CD4(+) T lineage integrity and couples effector differentiation to environmental cues after antigenic stimulation. ThPOK preserved the inte...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2960
更新日期:2014-10-01 00:00:00
abstract::Vaccines can have nonspecific effects through their modulation of responses to infections not specifically targeted by the vaccine. However, lack of knowledge about the underlying immunological mechanisms and molecular cause-and-effect relationships prevent use of this potentially powerful early-life intervention to i...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2961
更新日期:2014-10-01 00:00:00
abstract::In T lymphocytes, the mitogen-activated protein kinase (MAPK) p38 regulates pleiotropic functions and is activated by canonical MAPK signaling or the alternative activation pathway downstream of the T cell antigen receptor (TCR). Here we found that senescent human T cells lacked the canonical and alternative pathways ...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2981
更新日期:2014-10-01 00:00:00
abstract::Regulatory T (Treg) cells suppress the development of inflammatory disease, but our knowledge of transcriptional regulators that control this function remains incomplete. Here we show that expression of Id2 and Id3 in Treg cells was required to suppress development of fatal inflammatory disease. We found that T cell a...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2928
更新日期:2014-08-01 00:00:00
abstract::The catalytic activity of Zap70 is crucial for T cell antigen receptor (TCR) signaling, but the quantitative and temporal requirements for its function in thymocyte development are not known. Using a chemical-genetic system to selectively and reversibly inhibit Zap70 catalytic activity in a model of synchronized thymi...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2918
更新日期:2014-07-01 00:00:00
abstract::CD4(+) follicular helper T cells (T(FH) cells) are essential for germinal center (GC) responses and long-lived antibody responses. Here we report that naive CD4(+) T cells deficient in the transcription factor Foxp1 'preferentially' differentiated into T(FH) cells, which resulted in substantially enhanced GC and antib...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2890
更新日期:2014-07-01 00:00:00